Lorkof

Lorkof

Liquid transparent  orange syrup

Ingredients
10 ml syrup contains salbutamol sulphate in the equivalent amount of 2 mg salbutamol, 4 mg bromhexine hydrochloride, 100 mg guaifenesin, and 1 mg menthol.

Release Form
Syrup.

Pharmacotherapeutic Group
Adrenergic drugs for regular use. Salbutamol, combinations.

Drug Actions
Pharmacodynamics. Lorkof – a combination drug with bronchodilator, mucolytic and expectorant actions.
Salbutamol – selective beta-adrenoceptor agonist.  It has a high selective action on receptors in the bronchi  that causes bronchodilation; in therapeutic doses it has virtually no effect on the cardiac receptors.
Bromhexine – an effective mucolytic drug. It facilitates expectoration of viscous and purulent sputum from the respiratory passages.
Guaifenesin softens dry non-productive cough by reducing the sputum viscosity, increasing its volume, and facilitating expectoration.   
Menthol has an antispasmodic effect; it mildly stimulates the bronchial gland secretion, has antiseptic properties and improves the ciliated epithelium function of the bronchial mucosa.

Indications
Bronchial asthma.
Acute and chronic bronchitis.
Bronchiectasis.
Pertussis (Whooping Cough).
SARS and bronchopulmonary diseases accompanied by bronchospasm, mucus plugs within the bronchial tree, and heavy expectoration.

Use and Dosage
The dose of Lorkof for adults and children 12 years of age and older is 1-2 tablespoons (5-10ml) three times a day.
For children aged 3-6 years: 1 tablespoon (5ml) three times a day; for children aged 6-12 years – 1-2 tablespoons (5-10ml) three times a day.
Duration of treatment is 5-10 days.

Side Effects
The drug is well-tolerated, but in rare cases it can cause hand tremors, tachycardia, muscle cramps, headache, dizziness; gastrointestinal tract disorders - nausea, vomiting, diarrhea, abdominal pain; hypokalemia; and allergic reactions.

Contraindications
Hypersensitivity reactions to the drug components. Patients with tachycardia and cardiac rhythm disorders. First trimester of pregnancy. Children under 3 years old.

Overdose
Symptoms: tachycardia, headache, peripheral vasodilatation.
Treatment. Gastric lavage, induced vomiting, activated charcoal intake. Therapy – symptomatic.  

Peculiarities of Use
Lorkof syrup should be carefully prescribed in patients with hyperthyroidism, diabetes, serious cardiovascular diseases, arterial hypertension, gastric ulcer, and duodenal ulcer.
The drug is not used to eliminate bronchospasm.
Pregnancy and Breastfeeding.
Since there is no data about safety of using in pregnancy and breastfeeding period, the syrup should be prescribed only if its potential benefit to mother outweighs the expected risk to fetus or child.