Iodine Normil
Iodine Normil
Ingredients
1 Iodine-normil tablet contains 130,8 mcg or 261,6 mcg potassium iodide active substance equal to 100 or 200 mcg iodine, respectively.
Pharmacological Group
Drugs primarily affecting the tissue metabolism processes.
Iodine containing drugs.
Pharmacological Action
Iodine-normil is an inorganic iodine compound which replenishes iodine deficiency, thus normalizing the impaired synthesis of the main thyroid hormones. Iodine - normil significantly reduces the formation of inactive precursors of basic thyroid hormones.
When active substanceof Iodine-normil – potassium iodide norm enters the epithelial cells of the thyroid gland follicles under the iodide-peroxidase activity oxidation reactions occur that result in the formation of elemental iodine. After substitution reaction in the tyrosine aromatic ring it forms into 3rd and 4th iodo-derivatives (triiodothyronine and thyroxine, respectively). By binding to thyroglobulin the substances derived are deposited in colloidal material of the follicle, ensuring regulation of all stages of metabolic processes in the central nervous system, musculoskeletal system, reproductive system, and circulatory system.
In addition to the thyroid size normalization Iodine-normil normalizes intellectual-mental processes that, in general, maintain homeostasis.
Indications
Iodine-normil is used for preventing iodine-deficiency in gestation and lactation, as well.
In postoperative period in surgery of thyroid gland as a preventive medication against recurrent goiter.
Iodine-normil is widely used for treating the euthyroid syndrome in newborns and adults.
Use
The recommended Iodine-normil dose is determined as per individual characteristics of iodine quantification in food, taking human body needs into consideration.
Single daily dose, taken with water.
For convenience of administration in newborns and children under 3 years old the recommended drug dose should be dissolved in 5-10 ml boiled water at room temperature.
Use 50-100 mcg of the drug a day for preventing the occurrence of iodine deficiency in young children.
The daily dose of Iodine-normil in adolescents and adults is 100-200 mcg.
Similar dosage is used in pregnant and breastfeeding women – 1-2 tablets a day.
In the postoperative period after thyroid gland surgery, as well as at the end of thyroid hormone replacement therapy use 100–200 mcg of the drug a day for preventing goiter.
In euthyroid syndrome therapy in newborns it is required to take 100-200 mcg Iodine-normil a day. Adults and adolescents should take 200mcg of the drug per day.
Duration of the preventive therapy using Iodine-normil can count months, years. In some cases, it can last throughout the life span.
In newborns the duration of goiter therapy is 2-4 weeks, in adults and adolescents - up to one year. The duration of treatment should be determined by the attending physician individually.
Side Effects
Administration of preventive Iodine – normil dosages cannot cause any side effects, except for patients with large autonomous focuses of iron, or when the daily dose of the drug exceeds 150 mcg.
Side effects caused by Iodine- normil administration are based on the hyperthyroid phenomenon.
Side effects on the central nervous system caused by Iodine-normil administration include: sleep disturbances, excessive irritability, and emotional lability.
In blood picture – an increase in the number of eosinophils.
In addition, side effects caused by Iodine-normil administration might include increased sweating, salivation, increased peristaltic waves in the gastrointestinal tract, and diarrhea.
When high doses of Iodine -normil (200-300 mcg of the drug a day) are administered in elderly patients the likelihood of side effects increases.
Contraindications
Iodine-normil is contra-indicated in hyperthyroidism
The drug is contra-indicated in subclinical hyperthyroidism, in which the iodine doses are more than 150 mcg a day.
Duhring Dermatitis is a contraindication to the use of Iodine -normil.
The drug is not administered in patients with hypersensitivity reactions to its ingredients.
The presence of solitary thyroid cysts, functional autonomy areas, nodosa toxic goiter is not a reason for Iodine – normil administration.
Iodine-normil is also contra-indicated in patients with hypothyroidism, except for hypothyroidism.
Avoid using Iodine-normil concurrently with radioactive iodine in thyroid gland cancer treatment in case there is a suspicion of it.
The presence of lactose monohydrate in the drug formula makes it impossible to be administered in patients with congenital lactase deficiency, galactase, in glucose-galactose malabsorption.
Pregnancy
Increased need for iodine during gestation and lactation requires administration of sufficient Iodine-normil doses for ensuring homeostasis in mother and growing organism.
When determining the drug’s daily dose consider the alimentary iodine share.
Interaction with other drugs
When antithyroid drugs are concurrently administered with Iodine-normil , the clinical of effectiveness of both medications decreases.
Administration of potassium-sparing diuretics in patients taking high doses of Iodine-normil can cause hyperkalemia.
Simultaneous administration of Iodine normil with lithium drugs can cause goiter and development of hypothyroid symptoms.
In iodine replacement therapy Iodine- normil administration helps to stimulate the iodine absorption by the thyroid gland.