Vovenac Gel

Vovenac Gel

For quick relief of pain and inflammation

Ingredients  
Oleum Lini (B.P. Linseed Oil)
Mainly contains alpha - linolenic acid 3.00% w/w
Diclofenac Diethylamine B.P. Diclofenac sodium B.P. equivalent
Methyl salicylate B.P.
Menthol B.P.
Benzyl Alcohol B.P. (as a preservative)

Gel Base     
The gel base has a local anesthetic, warming and anti-inflammatory effect. Inhibits inflammatory mediators. Nonselectively blocks cyclooxygenase (COX-1 and COX-2) and exerts an inhibitory effect on the synthesis of prostaglandins, prostacyclin and thromboxane.  Its analgesic effect is mostly demonstrated in inflammatory pain: the drug relieves the pain syndrome in patients with pain at rest and in motion; it reduces morning joint stiffness and joint swelling; increases the range of motion. In addition to its anti-inflammatory effect, the gel base reduces platelet aggregation in the inflammation area, as well as decreases leukocyte migration and lysosomal enzymes release in the inflammation area.

Pharmacokinetics
When appling Vovenac gel to the skin, it rapidly penetrates into the deeper tissues (subcutaneous tissues, muscles, joints, and synovial fluid) and reaches therapeutic concentrations there. the therapeutic effect in the application area is achieved by direct spreading through the skin into the target tissues. Observed in blood plasma in small amounts. For recommended method of application the synovial fluid concentration is approximately 2 mcg/ml.    

Indications
- Inflammatory and degenerative diseases of the musculoskeletal system: joint syndrome in gout attack, arthritis (rheumatoid arthritis, psoriatic arthritis, and gouty arthritis), humeroscapular periarthritis, ankylosing spondylitis (Bekhterev’s Disease), deforming osteoarthritis, low back pain with radicular symptoms, radiculitis, tendonitis, tenosynovitis, bursitis , lumbago, and sciatica.
- Muscle pain (myalgia) of rheumatic and nonrheumatic type.
- Injuries (sport injuries, industrial injuries, household injuries, and etc.) without skin integrity impairment (dislocation, strains or breaks and sprains, bruises, post-traumatic swelling of soft tissues, and etc.).

Contraindications
Hypersensitivity reactions to ibuprofen, drug components, and other NSAIDs; bronchial asthma, urticaria, aspirin-induced rhinitis, moist dermatitis, eczema, skin integrity impairments in the gel application area, including infected wounds and abrasions; pregnancy (third trimester), children under 12 years old.  

Use with caution
In pregnant women (I and II trimester), breastfeeding women.

Use and Dosage
FOR TOPICAL APPLICATION! Apply 5-10 cm gel strips to the injured area and carefully rub with slow movements up to full absorption, 3-4 times a day. The duration of treatment depends on the severity of disease and type of injury, and is 2-3 weeks, in average.   

Side Effects
Usually the drug is well-tolerated. In rare cases, temporary signs of local skin irritation in the form of redness, swelling, rashes, itching, burning sensation and tingling can be observed.