Glizid M

Glizid  M

Combination medication for type 2 diabetes.

Ingredients
Metformin – 500 mg
Gliclazide - 80 mg

Pharmacological Action
Double-deficit compensation:
- Insulin secretion stimulation
- Insulin resistance reduction or overcoming С

Advantages of Metformin
Does not increase body weight.
Minimal risk of hyperglycemia.
Improves clinical outcomes in patients with type 2 diabetes and obesity:
- By reducing the concentration and oxidation of free fatty acids (FFA) and activating their re-esterification, metformin improves insulin-sensitivity.  
- Metformin therapy contributes to positive changes in the lipid spectrum: decrease in the triglyceride concentration, LDL
- Antithrombotic effect of metformin also reduces production of adhesion molecules and fibrinogen.
- Gliclazide the only sulfonylurea drug, whose efficiency in preventing serious complications in patients with diabetes has been proven.
- Reduces the risk of death attributed to cardiovascular disease (CVD) by 12 % and prevents the development of renal complications (decreases the risk of kidney disease by 21%).

Indications
Type 2 diabetes mellitus:
- Early combination therapy when diet therapy and monotherapy with peroral antidiabetic drugs are inefficient.
- Replacement of previous two-drug therapy ( metformin and gliclazide) in patients with type 2 diabetes mellitus with stable and well-controlled blood glucose levels.  

Use and dosage
- For oral administration, during or after eating.
- The drug dose is determined by the doctor individually for each patient depending on the blood glucose level.
- Usually, the initial dose is 1-3 tablets a day with gradual dose titration until stable compensation of the disease is reached.
- Normally, drug is administered twice a day (in the morning and at night).  

Contraindications
- hypersensitivity to metformin, gliclazide or other sulfonylurea derivatives, as well as excipients
- type 1 diabetes mettilus
- diabetic ketoacidosis, diabetic precoma, and diabetic coma
- hypoglycemia
- severe renal impairment;
- acute conditions that might result in changes in the kidney function: dehydration, severe infection, and  shock
- acute or chronic diseases accompanied by tissue hypoxia: cardiac or respiratory failure, recent myocardial infarction, and shock
- liver failure
- порфирия
- pregnancy, breast-feeding

Side Effects
- On metabolism: in dosage abuse  and inadequate diet – hypoglycemia; in some cases - lactic acidosis (weakness, myalgias, respiratory disorders, drowsiness, abdominal pain, hypothermia, low blood pressure, and reflex bradyarrhythmia).
- On the digestive system: dyspepsia (nausea, diarrhea, feeling of heaviness in the epigastric, “metallic” taste in the mouth), loss of appetite - the severity is reduced by taking the drug when eating.